Cancer Types - Kidney (Renal Cell) Cancer
Most cancers are named after the part of the body where the cancer first begins, and kidney cancer is no exception. Kidney cancer begins in the kidneys, two large, bean-shaped organs - one located to the left, and the other to the right of the backbone. Renal is the Latin word for kidney, and kidney cancer may also be referred to as renal cancer.
Nearly 54,390 persons in the US are expected to be diagnosed with kidney and pelvic renal cancers in 2008, with the most common type called renal cell cancer. The information contained on this page refers to renal cell cancer.
The exact cause of renal cell cancer is unknown. However, there are certain risk factors that increase the likelihood of the disease. These risk factors, according to the American Cancer Society, are as follows:
Smoking increases the risk of kidney cancer. The risk seems related to the amount you smoke.
Studies show a link between exposure to asbestos and kidney cancer.
There may be a link between cadmium exposure and kidney cancer. Cadmium may increase the cancer-causing effect of smoking.
- family history
Family history of kidney cancer increases a person's risk.
Men are twice as likely to develop renal cell cancer than women.
- von Hippel-Lindau syndrome
This is a disease caused by a gene mutation that increases the chances of renal cell cancer.
- tuberous sclerosis
Patients who have this disease are more likely to develop renal cell cancer.
A high-fat diet increases a person's risk of kidney cancer.
Obesity increases a person's risk of kidney cancer.
- long-term dialysis
Patients who have been on dialysis for a long time may develop kidney cysts, which may be one cause of renal cell cancer.
- high blood pressure
Patients who are overweight and have high blood pressure may have a risk for kidney cancer that is three times greater than patients who are not overweight and who have normal blood pressure.
- diuretics (water pills)
Drugs that eliminate excess body fluid have been linked to kidney cancer.
African Americans have a slightly higher risk of kidney cancer.
The following are the most common symptoms of renal cell cancer. However, each individual may experience symptoms differently. Symptoms may include:
- blood in the urine
- rapid, unexplained weight loss
- low back pain (not caused by an injury)
- loss of appetite
- swelling of ankles and legs
- mass or lump in the belly
- recurrent fever (not caused by a cold or the flu)
- high blood pressure (less frequently)
- anemia (less frequently)
- unrelieved pain in the side
The symptoms of renal cell cancer may resemble other medical conditions or problems. Always consult your physician for a diagnosis.
In addition to a complete medical history and physical examination, diagnostic procedures for kidney cancer may include the following:
- blood and urine laboratory tests
- intravenous pyelogram (IVP) - a series of x-rays of the kidney, ureters, and bladder with the injection of a contrast dye into the vein - to detect tumors, abnormalities, kidney stones, or any obstructions, and to assess renal blood flow.
- renal angiography (Also called arteriography.) - a series of x-rays of the renal blood vessels with the injection of a contrast dye into a catheter, which is placed into the blood vessels of the kidney, to detect any signs of blockage or abnormalities affecting the blood supply to the kidneys.
- other imaging tests (to show the difference between diseased and healthy tissues), including the following:
- computed tomography scan (Also called a CT or CAT scan.) - a noninvasive procedure that takes cross-sectional images of the brain or other internal organs; to detect any abnormalities that may not show up on an ordinary x-ray.
- magnetic resonance imaging (MRI) - a noninvasive procedure that produces two-dimensional (2D) view of an internal organ or structure, especially the brain and spinal cord.
- ultrasound (Also called sonography.) - a diagnostic imaging technique that uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs. Ultrasounds are used to view internal organs as they function, and to assess blood flow through various vessels.
- chest x-ray - a diagnostic test which uses invisible electromagnetic energy beams to produce images of internal tissues, bones, and organs onto film.
- bone scan - a nuclear imaging method to evaluate any degenerative and/or arthritic changes in the joints; to detect bone diseases and tumors; to determine the cause of bone pain or inflammation.
Based on results of other tests and procedures, a biopsy may be needed. A biopsy is a procedure in which a sample of the tumor is removed and sent to the laboratory for examination by a pathologist. Biopsy is the only sure way to diagnose cancer.
Specific treatment for kidney cancer will be determined by your physician based on:
- your age, overall health, and medical history
- extent of the disease
- your tolerance for specific medications, procedures, or therapies
- expectations for the course of the disease
- your opinion or preference
Treatment may include:
New chemotherapy drugs and targeted therapies including thalidomide, Avastin® (bevacizumab), Nexavar® (sorafenib), and Sutent® (sunitinib) are being used to treat kidney cancer. A vaccine for treatment also is under study.
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